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The Gordon Research Seminar on the Biology of Spirochetes is an excellent venue for early-career researchers in the diverse field of spirochetes to present their findings and to network with peers. The 2020 fourth edition BoS GRS will include presentations from all major groups of spirochetes and fields of research, including bacterial physiology, epidemiology, and host-pathogen interactions involving this unique bacterial family. State of the art and breaking research will be highlighted in addition to opportunities to discuss and collaborate with researchers from all over the world.